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For more on the science of metabolic hormones, check UC Davis' white paper

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This deterioration is accelerated by sun exposure (photoaging), hormonal changes (particularly menopause), smoking and pollution, chronic inflammation, and a poor diet

Brain oxidative stress: detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy