Two choice examples from the archives: 2006: Rite-Aid + Brooks-Eckerd: Will three wrongs make it Rite
A 36 mg dose of the drug, taken once per day without food and water restrictions, reduced weight by an average of 12.4%, compared to 0.9% for participants in the placebo group
NICE guidelines emphasise lifestyle modification and licensed medications (orlistat, semaglutide) for weight management rather than food supplements
This is not a replacement for trials, but it can move much faster, and that speed matters when a drug goes from niche to mainstream almost overnight. A major challenge in this process, which Guntuku calls computational social listening, has been scale
This requires a medical procedure such as rubber band ligation, laser, infrared light, or hemorrhoidectomy (surgical removal of the hemorrhoids)
Since weight loss hadnt plateaued in either orforglipron study, I consider orforglipron a superior oral option