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In the eye, Sosne et al., Exp Eye Res 2001 reported accelerated corneal re-epithelialisation and reduced inflammation after injury, and in the central nervous system Xiong et al., J Neurosurg 2012 found that T4 initiated six hours after experimental traumatic brain injury improved sensorimotor and spatial-learning recovery while enhancing hippocampal neurogenesis

Ross GW, Petrovitch H, Abbott RD, Nelson J, Markesbery W, Davis D, Hardman J, Launer L, Masaki K, Tanner CM, White LR: Parkinsonian signs and substantia nigra neuron density in decendents elders without PD

At the same time , studies explore how peptide-mediated signaling participates in regulatory processes across different tissue types

~ Ann N Y Acad Sci

Nature Medicine, 30(6), 1639-1647