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The problem inherently is that were not quite sure what it is that causes all this benefit

As mentioned, Semaglutide has been approved by the FDA in 2021

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"Way back, when there really weren't too many other agents for obesity treatment," she'd prescribe more of it, she told Insider, but that was largely because "there wasn't anything else." But metformin's effects on weight loss are "kind of mild," compared to newer drugs like semaglutide, Apovian said, and persistent side effects like stomach cramps and diarrhea are a common concern among patients taking metformin

Semaglutide slows down digestion, making food pass through the stomach more slowly