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People with type 2 diabetes Tirzepatide dual mechanism provides additional metabolic benefits beyond weight loss

However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists

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Weight regain after GLP-1 therapy has become a growing concern as more patients discontinue treatments like semaglutide or liraglutide