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J.PruvostC.JouaninL

J Transl Med , 13: 42, 2015

John Trojanowski (University of Pennsylvania)

Activated Y1234 and Y1235 upregulate kinase activity and result in phosphorylation of the docking site residues Y1349 and Y1356, leading to the recruitment of adaptor proteins and signaling molecules

HGF/c-Met receptor activation: Dihexa binds to and activates the hepatocyte growth factor (HGF) and c-Met receptor system, a powerful signaling pathway involved in cell growth, repair, and neurogenesis