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Some helpful tips for managing gastrointestinal side effects include: Stay well-hydrated Eat smaller meals Avoid fatty or spicy foods when first starting Take the medication consistently on the same day each week Consider taking it at bedtime so you sleep through initial effects More serious side effects are rare but include pancreatitis, kidney problems, and allergic reactions

Thus, weight loss maintenance with GLP-1RA may act to prevent pre-diabetes in obesity

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Options include testosterone therapy, bioidentical hormone replacement, and hormone pellet therapy

Ethics statement The studies involving human participants were reviewed and approved by the Institutional Ethical Committee of Reina Sofia Hospital, Cordoba, Spain (protocol no 228, ref 2466

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