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Semaglutide muscle loss and similar effects with other GLP-1s are more about the speed of weight loss and low protein than the drug itself
Oxid Med Cell Longev 2017:3281670
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This is a serious problem for several reasons: Muscle loss slows your resting metabolic rate, making it harder to keep weight off after stopping the medication Reduced muscle mass increases the risk of falls, fractures, and loss of physical function particularly in older adults The skinny fat phenomenon normal BMI but high body fat percentage is a real outcome of poorly managed GLP-1 use The solution is not to avoid GLP-1 medications
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