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Apply to damp skin for optimal absorption

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Lori Laffel, MD, MPH Senior Investigator, Chief, Pediatric, Adolescent, and Young Adult Section Section Head, Clinical, Behavioral and Outcomes Research Co-Director, Clinical Translational Research Core, Joslin Diabetes Center Professor of Pediatrics, Harvard Medical School Website: Expertise: Lori Laffel, MD, MPH, focuses her research and clinical interests on preventing the late complications of type 1 diabetes and preserving the health, normal growth, development and family functioning of children, adolescents and young adults with diabetes

While most patients do not experience mood changes, higher-risk groups include: History of depression, anxiety, or bipolar disorder ADHD or dopamine-sensitive conditions Very rapid weight loss Inadequate protein or electrolyte intake Poor sleep quality Lower risk is associated with: Slow dose titration Adequate nutrition Stable blood sugar Good sleep hygiene What Clinicians and Patients Can Do Before Starting a GLP-1 Screen for mood disorders Set expectations about appetite changes Discuss minimum nutrition goals During Treatment Monitor caloric intake (not just weight) Prioritize protein and hydration Watch for glucose variability Adjust dose slowly If Irritability Appears Assess nutrition first Evaluate sleep and reflux Consider dose adjustment Monitor mood over time In many cases, simple nutritional adjustments or slower titration resolve symptoms without stopping the medication

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Youve had a serious allergic reaction to tirzepatide