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Melanotan II's lactam bridge between the Asp and Lys side chains constrains the peptide into a rigid cyclic conformation that dramatically reduces the conformational entropy penalty upon receptor binding, resulting in higher binding affinity at melanocortin receptors compared to linear analogs of equivalent sequence

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In the case of class 1 inhibitors, including saxagliptin and vildagliptin, two primary binding sites, S 1 and S 2 , are coordinated by clusters of amino acid residues

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