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These medicines include: Rare cases of drug-induced vitiligo have also been reported from: Note: phenols that cause localised contact leukoderma, such as monobenzyl ether of hydroquinone, paraphenylenediamine and rhododendrol, may also cause generalised vitiligo in rare cases

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The cycle structure exists for a practical reason: continuous stimulation of the same receptor pathways can lead to reduced sensitivity over time, and a rest period allows the system to reset before the next cycle produces full effect