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This is especially true when introducing glutathione supplement, as they can potentially lead to irritability

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In the ER, the glutathione concentration is around 15 mM, higher than in whole cell lysates with around 7 mM (Birk et al., 2013)

A curved arrow points upward from 5-methylTHF to THF, indicating that THF is regenerated after methyl-group donation to homocysteine