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The conventional framing of HRT as a symptom management tool, addressing hot flashes, sleep disruption, and genitourinary changes, captures only part of its biological relevance

doi: 10.1002/ejhf.1536 50 PackerMAnkerSDButlerJFilippatosGPocockSJCarsonPet al

doi: 10.20892/j.issn.2095-3941.2019.0158 27 ZhuZShenHXuJFangZWoGMaYet al

This process creates a highly reactive and potentially toxic byproduct called NAPQI (N-acetyl-p-benzoquinone imine)

Specifically, we emphasize that dietary polyphenols mitigate radiation-induced inflammation primarily through robust ROS scavenging pathways and DNA damage repair mechanisms

Most medical and experimental protocols emphasize a conservative, progressive approach, beginning with minimal exposure to assess tolerance and biological response