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Peptides containing positively charged amino acids (histidine, lysine, arginine) bind to TAS2R bitter taste receptors with high affinity, triggering the same neural pathways activated by quinine and other alkaloids

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J Ocul Pharmacol Ther 30:700708 Alici O, Kavakli HS, Koca C, Altintas ND, Aydin M, Alici S (2015) Value of caffeic acid phenethyl ester pretreatment in experimental sepsis model in rats

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