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Before combining medications, discuss optimizing your current therapy by ensuring adequate dosing and treatment duration, exploring FDA-approved alternatives like tirzepatide or phentermine-topiramate ER, intensifying lifestyle interventions with behavioral therapy, or considering metabolic surgery if you meet clinical criteria

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Although some supply constraints have eased since early shortages were declared for several GLP-1 receptor agonists, access and GLP-1 shortage concerns persist as utilization continues to outpace production in certain segments of the market

Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z