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and expressed these mutant cDNAs in SLC25A39 knockout HEK-293T cells (Fig

16 This mechanism has been further strengthened by in vivo evidence from murine bilateral renal ischemia-reperfusion injury models, in which vesicles released from injured tubules have been shown to carry the long non-coding RNA WAC-AS1 and suppress antioxidant defenses in neighboring tubular cells

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