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The glycine part forms three hydrogen bonds with R289 and N345, with an average binding energy of 5.6 kcal/mol

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Specific CYP3A4 inhibitors like troleandomycin have been shown to inhibit AFBO production [29], while inducers of CYP3A4 activity such as 3-methylcholanthrene and rifampicin, increase AFB 1 metabolism in cultured human hepatocytes [49]

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