In the brain, it acts on hypothalamic circuits to curb appetite, confirmed in animal feeding and fMRI studies
Amino acids are sensitive biomarkers for assessing GCGR activity of GCGR/GLP-1R dual agonists, as plasma amino acid levels are reduced independently of insulin and glucose levels and GLP-1R activity [27, 28]
But this may well change Sanofi is cutting the price of Praluent in the US to try and gain market share from Amgen this year
The bottom line GLP-1 drugs do not reduce fat despite insulin
Look for fiber-rich foods like: Fruits (apples, berries, citrus) Vegetables (Brussels sprouts, sweet potatoes) Whole grains (oats, barley) Seeds (chia, flax) As you add fiber to your diet, be sure to increase your intake gradually and drink plenty of water to avoid digestive discomfort
Good rest greatly improves focus and mood