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Semaglutide : SUSTAIN trials showed HbA1c reduction of 1.5-2.2%
doi: 10.1016/j.dsx.2018.03.002 94 OrskovCWettergrenAHolstJJ
This is followed by the release of nesfatin-1 which stimulates cholecystokinin secretion leading to a rise in bile salts from gallbladder emptying, and the binding of Takeda P protein coupled receptor 5 (TGR5) onto the surface of the enteroendocrine cells, all of which eventually culminates in GLP-1 secretion [9]
The result is a drug that reduces how much you eat, improves how your body processes sugar, and increases how many calories your body burns, all at once
GLP-1 receptor activation enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system effects
Barbagallo M, Dominguez LJ
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