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It is typically characterized by a reduction in alpha diversity (species richness), a decrease in beneficial butyrate-producing bacteria (e.g., Faecalibacterium , Roseburia , Lachnospiraceae ), and an increase in potentially pro-inflammatory bacteria or pathobionts (e.g., Proteobacteria like Escherichia ) (Acevedo-Romn et al., 2024
Peptide linkers are the most widely used enzymatically cleavable linkers