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doi: 10.3390/antiox13020200 19 FordCEWernerBHackerNFWartonK
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This binding triggers an inflammatory response, activating nuclear factor-kappa B (NF-B) and mitogen-activated protein kinases (MAPKs), leading to the production of pro-inflammatory cytokines such as TNF- , IL-1, and IL-6 (55)
The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA
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