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2M is a homotetrameric glycoprotein with MW of 720 kD 16 responsible for binding and inactivation of proteases 17
Kim DK, Kim SJ, Kang SS, Jin EJ
doi: 10.4049/jimmunol.146.6.1914 204 McDowellA.BarnardE.LiuJ.LiH.PatrickS
Hypotheses 144 , 110242 (2020)
It works by reducing the production of the signal molecule , interleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time
This means the window between effective and miserable narrows sharply when stacking them
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