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With thoughtful nutrition, monitoring, and collaboration with healthcare providers, some parents may be able to continue breastfeeding while using GLP-1 medications

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Possible Side Effects: While generally safe, some people may experience mild nausea or stomach irritation, usually when the dosage is too high

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Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Fig