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The presence of multiple GSTs with overlapping functions and substrate specificities might preclude the observation of phenotypic alteration in knockout mutants (Sappl et al., 2009)
Transcriptomic analyses indicate broad influence over genes related to inflammation, repair, and cellular maintenance
Crystal structures have been deposited in the RCSB Protein Data Bank (PDB IDs: 2XPD, 9F5V, 3ZRD, 9F64, 9F65)
KLOWs mechanism of enhancing insulin sensitivity through AMPK activation overlaps with metformin and GLP-1 receptor agonists, creating theoretical hypoglycemia risk when combined without dose adjustment
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