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However, roFPs only measure the changes in redox potential ( E GSH ) in cells, which can be due to shifts in the [GSH]:[GSSG] ratio, changes in total GSH concentration, or a combination of both scenarios

Indeed, recent elegant studies in humans and collecting duct cell lines showed that IGF-1 regulates sodium reabsorption in the distal nephron by activation of the IGF-1R, which results in upregulation of the ENaC [25, 26]

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Mari M, Morales A, Colell A, Garcia-Ruiz C, Fernandez-Checa JC

doi: 10.1007/s007020170059 108 LindayL