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This behavior has been attributed to the diluted culture media that severely limit extracellular post-translational modifications of collagen, namely the cleavage of the C propeptide, a reaction catalyzed by C-proteinase/bone morphogenetic protein 1 (BMP1), and the formation of covalent cross-links, initiated by members of the lysyl oxidase (LOX) family 5,6

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation