Neither has passed the phase 2-3 stages required for marketing authorization
BPC-157 enhanced growth hormone receptor expression and angiogenesis pathways while reducing inflammatory cytokines including IL-1beta and TNF-alpha
Both oxidative stress and TNF have been critically implicated in the progression of NAFLD 5
Bates SE, Berry DA, Balasubramaniam S, Bailey S, LoRusso PM, Rubin EH (2015) Advancing clinical trials to streamline drug development
Chang, C.-H., et al., The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
Quick answer: In the Phase 2 clinical trial (Jastreboff et al., 2023, New England Journal of Medicine ), retatrutide was given by once-weekly subcutaneous injection across a 112mg range