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Janvier, S., Cheyns, K., Canfyn, M., Goscinny, S., De Spiegeleer, B., Vanhee, C., & Deconinck, E

Alternative GLP-1 receptor agonists If semaglutide causes significant side effects or concerns about b12 status arise, other GLP-1 medications offer alternatives

J Clin Endocrinol Metab, 95(9), 42914304

Whilst oral absorption is limited, regular consumption of mega-doses can elevate serum levels substantially

Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption

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