The SOUL Trial (Oral Semaglutide): McGuire DK, et al
Aljabri AA (2026)
Still, it may be relevant to perform pilot studies to address whether the therapy will benefit selected HFrEF cohorts with obesity.
The pattern: nausea returns within days of the dose increase, peaks during the first one to two weeks at the new dose, and improves over the following two to three weeks as your body adapts to the new steady state
That raises a critical question about whether or not a patient [on ts- or bDMARDs] would actually see any further improvement adding GLP-1 RAs, he said
What You'll Need Required Supplies Retatrutide vial (lyophilized powder, typically 5mg, 10mg, or 15mg) Bacteriostatic water (BAC water): contains 0.9% benzyl alcohol as preservative Insulin syringes (U-100, 0.5mL or 1mL with fine gauge needle) Alcohol swabs (70% isopropyl alcohol) Optional but Recommended Larger mixing syringe (3mL) for adding BAC water Sharps container for safe needle disposal Clean workspace with good lighting Vial labels to mark reconstitution date and concentration Do NOT use: Sterile water or saline without preservative