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doi:10.1016/j.pep.2011.05.012
In cancer, inducers of ferroptosis, such as erastin and RSL3, take advantage of the high levels of iron and PUFAs in tumor cells [94, 95], while inhibitors like fer-1 and liproxstatin-1 show potential in treating neurodegenerative diseases, including Alzheimers, where lipid peroxidation contributes to neuronal damage [96]
Franklin, C.C., et al., Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
American Journal of Therapeutics
B.ZhouZ.LuchiniD.CardosoF
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