Some studies have looked at it in combination with other ingredients, including folic acid
Additionally, lactate from astrocytes can regulate the electrophysiological activity of orexin neurons
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Here are the most common: Nausea Vomiting Diarrhea Constipation Stomach pain These side effects are mostly gastrointestinal, which is why Rothberg advises caution for people with pre-existing digestive issues, such as delayed gastric emptying or reflux disease
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PLoS ONE 3 , e3898 (2008)