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Higher-order thiol cell systemsthe metallothioneins, thioredoxins, and other redox regulator proteinsare ultimately regulated by GSH levels and the GSH/GSSG redox ratio

Side Effect Mitigation The primary motivation for microdosing is reducing adverse effects: Theoretical advantages: Lower peak concentrations reduce nausea intensity Gradual exposure allows GI adaptation Reduced gastroparesis severity Better maintenance of normal eating patterns 2

That said, clinical data gives us a good picture of what is achievable

Feng C, Yan M

MEOS uses a different enzyme (Cytochrome P450 2E1 - CYP2E1) to metabolize ethanol, but still creates toxic acetaldehyde