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The numbers are definitive

Prolonged B12 deficiency can cause irreversible neurological damage, including peripheral neuropathy, cognitive decline, balance problems, and mood disturbances

Therefore, more research is necessary to validate findings from preliminary and small scale studies

When to reduce dose or stop Reduce your dose if side effects are persistent (lasting more than a few days), interfere with daily activities, or worsen rather than improve over time

Headaches associated with GLP-1 therapy are typically most common during the initial weeks of treatment or following dose escalation

Olsen S, Aagaard P, Kadi F, et al