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Lean mass preservation during GLP-1based weight loss: why body composition matters A key translational issue in GLP-1RA-based obesity therapy is that substantial weight loss does not automatically translate into favorable body-composition outcomes

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A Note for Canadian Researchers Health Canada has not yet reviewed Retatrutide, as Eli Lilly has not submitted a New Drug Submission (NDS) for the Canadian market

That is a body composition change that affects blood pressure, joint load, metabolic markers, and energy levels in a measurable way

Phase III randomized trials demonstrated a 15 percent reduction in visceral adipose tissue over 26 weeks compared to placebo