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Can Med Assoc J 12(3):1416 Holt RIG, DeVries JH, Hess-Fischl A et al (2021) The management of type 1 diabetes in adults
[PMID: 21140244] PubMed record related to this compound for laboratory literature review
The past few years have transformed obesity, bringing it into the fore as one of the fastest growing therapy areas in global healthcare
Semaglutide 2.4 mg (Wegovy): ~15% body weight loss at 68 weeks in clinical trials Tirzepatide 15 mg (Zepbound): ~21% body weight loss at 72 weeks in clinical trials Real-world data shows lower results: Cleveland Clinic research from 2025 found average weight loss of 7.7% with semaglutide and 12.4% with tirzepatide at one year in routine clinical practice
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Higher doses do not necessarily produce greater safety risks if titration is slow and medical supervision is active
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