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Rosenstock, J., Fras, J
At the highest dose, average weight loss reached 21-22% of baseline body weight, with approximately 85% of participants achieving at least 5% weight reduction and 70% achieving 15% or greater reduction
While the GLP-1s affected familiar territory, they also triggered activity in the central amygdala, a region associated with desire that is deeper in the brain than scientists previously thought GLP-1s could directly reach
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When trials were done on these drugs, researchers used the dosages unique to each drug and were looking for different results (Wegovy trials looked at the extent of weight loss, whereas Ozempic trials looked at the extent of glycemic control). Currently, a box of four pens of Wegovy (which is a 1-month supply) costs $1,400
Its gastrointestinal effects stem from slowed gastric emptying and altered gut motility, not from impaired enzyme production or secretion
