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Foundational Pharmacology & Diet-Induced Obesity Study (Biochemical Pharmacology, 2018) Selective NNMT Inhibition Reverses Diet-Induced Obesity in Mice The foundational published study of 5-Amino-1MQs pharmacological characterisation and in vivo efficacy was published in Biochemical Pharmacology

Simplified research hypothesis: 5-Amino-1MQ inhibits NNMT 1-methylnicotinamide production falls nicotinamide and methyl-donor pathways change downstream metabolic measurements may change in selected cell and animal models

It works, at least in part, by activating the FAKpaxillin pathway in cells

Depending on the clinical trial, more treated participants lost 5% up to 15% of their initial body weight vs

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High levels of B12, or hypercobalaminemia, can be a sign of tissue breakdown, which releases B12 back into the bloodstream