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The upregulation of ovarian tumor deubiquitinase 5 deubiquitinates and stabilizes GPX4, reversing 4-HNE-induced ferroptosis, revealing the mechanistic role of 4-HNE in GPX4-dependent ferroptosis [32]
L-carnitine is a naturally occurring amino acid derivative synthesized primarily in the liver and kidneys from the essential amino acids lysine and methionine
Most studies have focused on specific medical conditions over relatively short periods
Targeted delivery minimizes systemic exposure and focuses action on the tissue that requires repair, reducing off-target proliferation risk
The penetration of nanocarriers was followed from the donor (upper) to the acceptor (lower) compartment mimicking blood to brain direction
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