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Early studies suggest possible effects on cravings, but evidence remains limited
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Avoid repeated temperature cycling, and never freeze a reconstituted vial, which can precipitate the peptides out of solution
The significant 17% relative risk reduction in fatal/nonfatal stroke in the meta-analysis of 8 CVOTs with GLP-1RAs is numerically similar to many of the proven interventions for stroke reduction in diabetes that were described earlier (ie, acetylsalicylic acid, 14 statins, 15 blood pressure lowering, ramipril, 11 low-dose rivaroxaban, 17 icosapent ethyl, and evolocumab 19
Avoid magnesium oxide, which has poor absorption and can worsen diarrhea
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