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Using the optogenetic-microdialysis method, evidence was also obtained for the ability of the equilibrative nucleoside transporter dipyridamole, which increases the extracellular levels of adenosine, to significantly inhibit cortico-striatal glutamate in control rats and in rats with BID (113)

Am J Clin Nutr 94:938944 Yamada M, Kuroda H, Shimoyama S, Ito R, Sugama Y, Sato K, Yamauchi N, Horiguchi H, Nakamura H, Hamaguchi K, Abe T, Fujii S, Maeda M, Kato J (2016) Efficacy of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in patients with chronic myelogenous leukemia

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Instead of forcing a response, it appears to remove bottlenecks and enhance processes that are already trying to happen

By selectively disrupting key antioxidant systemssuch as inhibiting glutathione synthesis with buthionine sulfoximine (BSO), blocking thioredoxin reductase with auranofin, or directly targeting NRF2therapies can push cancer cells beyond their limited oxidative buffering capacity