Step 3: Rotate Injection Sites Always rotate between sites (left abdomen, right abdomen, thighs) to prevent lipodystrophy thickened tissue that can reduce absorption
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Research published in The AAPS Journal confirms subcutaneous injections bypass enzymatic degradation and first-pass metabolism, resulting in higher systemic exposure and tighter control over therapeutic concentrations
Duan L, Woolbright BL, Jaeschke H, Ramachandran A
The Cleveland Clinic study found that 27% of people who stopped their GLP-1 switched to a different medication within 12 months
While this is generally a positive health benefit, people who take blood pressure meds may need to reduce the dosage while theyre on Ozempic, and will need regular monitoring to ensure their blood pressure doesnt drop too low