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They have the GLP-1 receptor, they're activated, but there also is an inhibitory tone on the AgRP and NPY neurons, and it fits very well with that
Theres also typically ongoing Phase 4 monitoring after launch to track long-term safety and effectiveness in the broader population
Gradual progressionincreasing every 24 weeks by 0.25 mL incrementsallows tolerance assessment and side effect monitoring
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