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The prognostic value of hypoxia-inducible factor-1alpha in advanced cancer survivors: a meta-analysis with trial sequential analysis

This finding may be attributed to the presence of considerable amounts of ascites, which creates a favorable environment for the survival of tumor cells (80)

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66,67 In addition, ferroptotic cancer cells secrete extracellular factors, including LGALS13, that modulate the antioxidant state of adjacent cells, thereby priming them for subsequent ferroptotic collapse