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We started follow-up on the day after cohort entry and continued until outcome occurrence or until any of the following occurred: treatment discontinuation or starting a drug in the comparator class, death, end of continuous health plan enrollment, or end of available data

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However, long-term use of proton pump inhibitors may increase the risk of gastric cancer, kidney disease, and other complications 42,43,44

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They persist for the entire week between injections because the drug has been engineered for sustained activity