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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner
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While semaglutide does not require dose adjustment for mild to moderate renal impairment, experience in patients with severe renal impairment is limited
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