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The addition of GIP agonism is what separated tirzepatide from pure GLP-1 drugs, and researchers tracking the progression from semaglutide to tirzepatide to retatrutide can see how each additional receptor adds another layer of metabolic benefit

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Cell Death Dis 13(3):271 Lin Y, Cai Q, Chen Y, Shi T, Liu W, Mao L, Deng B et al (2022b) CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase