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Kobayashi A et al

The remaining authors declare no competing interests

The most common side effects are nausea (reported by 44% of patients in the STEP 1 trial), diarrhea (30%), vomiting (24%), and constipation (24%)

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DSIP is proposed to interact with components of the MAPK cascade via this mechanism providing a potential molecular basis for its glucocorticoid-related biology, anti-proliferative activity, and stress-protective effects

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