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PMID 10743980

The body adjusts during a break, and restarting at the previous dose without re-titration leads to a strong return of GI side effects

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proliferation, migration, and invasion), in PC3 and LNCaP cells regardless of their hormone sensitivity

Warning: The prescribing information advises patients using oral hormonal contraceptives to switch to a non-oral method or add a barrier method for four weeks after starting and four weeks after each dose increase