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Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (18, 2931, 70)
The risks are real and unknown
Anal Biochem (1976) 72:24854.10.1016/0003-2697(76)90527-3 16 ZhaoHJosephJZhangHKarouiHKalyanaramanB
et al.: Methionine Nutrition and Metabolism: Insights from Animal Studies to Inform Human Nutrition
Retrieved 29 March 2014
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