Common side effects include dry mouth, insomnia, restlessness, elevated heart rate, irritability, and constipation
Tirzepatide (Mounjaro, Zepbound) activates two receptors, GLP-1 and GIP
Risk of Incident Heart failure in patients with diabetes and asymptomatic left ventricular systolic dysfunction
Onset timing varies: some patients experience headache within days of initiation, while others develop it during dose escalation to therapeutic ranges
Cost considerations without insurance (as of 2025): Wegovy (semaglutide): approximately $1,300-$1,500 per month Saxenda (liraglutide): approximately $1,300-$1,400 per month Zepbound (tirzepatide): approximately $1,000-$1,200 per month These prices reflect list prices
I think my biggest takeaway is that GLP-1 medications operate on a far deeper level than the vast majority of people think